Predictive biomarkers to anti-VEGF therapy: Progress toward an elusive goal

Abstract

The search for reliable biomarkers predictive of response to anti-VEGF therapy has been elusive. VEGF-A, the therapeutic target of bevacizumab, is an intuitive candidate as a predictive biomarker to bevacizumabbased anticancer therapy. However, there remains much controversy in the use of VEGF-A as a predictor of response to bevacizumab. Copyright © 2013 American Association for Cancer Research.