Physostigmine in the Treatment of y-Hydroxybutyric Acid Overdose

Abstract

The widespread abuse of the recreational drug γ-hydroxybutyric acid has resulted in several reports of overdose leading to coma. The use of a short-acting anticholinesterase agent such as physostigmine as a potential reversal agent has been proposed previously. We report 2 cases of γ-hydroxybutyric acid-induced coma that rapidly reversed with intravenous administration of physostigmine. © 2000 Mayo Foundation for Medical Education and Research.