Background: Intralipid® and heparin infusion results in increased blood pressure and autonomic abnormalities in normal and hypertensive individuals. Objective: To evaluate insulin sensitivity and the impact of Intralipid® and heparin (ILH) infusion on hemodynamic, metabolic, and autonomic response in patients with the indeterminate form of Chagas' disease. Methods: Twelve patients with the indeterminate form of Chagas' disease and 12 healthy volunteers were evaluated. Results: Baseline blood pressure and heart rate were similar in both groups. Plasma noradrenaline levels were slightly increased in the Chagas' group. After insulin tolerance testing (ITT), a significant decline was noted in glucose in both groups. ILH infusion resulted in increased blood pressure in both groups, but there was no significant change in plasma noradrenaline. The low-frequency component (LF) was similar and similarly increased in both groups. The highfrequency component (HF) was lower in the Chagas' group. Conclusion: Patients with the indeterminate form of Chagas' disease had increased sympathetic activity at baseline and impaired response to insulin. They also had a lower high-frequency component and impaired baroreflex sensitivity at baseline and during Intralipid® and heparin infusion.
CITATION STYLE
Silva, C. C. S., Santos, C. A. M., Mostarda, C., Krieger, E. M., & Lopes, H. F. (2012). Blood pressure, metabolic and autonomic responses to insulin and intralipidspi® infusion in chagasic patients. Arquivos Brasileiros de Cardiologia, 98(3), 225–233. https://doi.org/10.1590/S0066-782X2012005000018
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