The association between Vitamin D level and restless legs syndrome: A population-based case-control study

Abstract

Study Objectives: The pathophysiology of restless legs syndrome (RLS) may be related to abnormalities in central dopamine pathways. Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system. The aim of our study is to examine the possible link between RLS and Vitamin D deficiency. Methods: The total number of subjects enrolled was 201, including 78 patients with RLS based on the International RLS Study Group (IRLSSG) diagnostic criteria and 123 controls. Serum 25-hydroxy Vitamin D levels were measured in both groups. RLS severity was assessed in all cases using the IRLSSG symptom severity rating scale. Results: Fifty-nine patients with RLS (75.6%) and 52 controls (42.3%) had a diagnosis of Vitamin D deficiency, P < 50 nmol/L compared to those with a Vitamin D level ≥ 50 nmol/L (P