EPIC early detection of ovarian cancer

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Abstract

CA125 dominated performance for ovarian cancer early detection among four serum biomarkers evaluated in EPIC study prediagnostic serum, rising on average 3 years prior to detection. Adding HE4 provided only marginal improvement. This natural history supports annual testing for early detection and highlights the importance of biomarker discovery complementing CA125.

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Skates, S. J. (2016). EPIC early detection of ovarian cancer. Clinical Cancer Research, 22(18), 4542–4544. https://doi.org/10.1158/1078-0432.CCR-16-1391

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