Effect of Glutaraldehyde on Dentin Hypersensitivity after Non-surgical Periodontal Therapy: A Randomized, Triple-blinded Clinical Study

Abstract

Aims and Objectives: The purpose of this study was to evaluate the effect of 5% glutaraldehyde (5% Gluma), in association with 37% phosphoric acid conditioning, on dentin hypersensitivity (DH) after non-surgical periodontal treatment (NSPT). Additionally, we investigated the impact of these treatments on health-related quality of life (HRQoL). Method(s): Ninety hypersensitive teeth of subjects were randomized into the following three groups based on treatment (n = 30): GP: placebo gel that simulates 37% phosphoric acid (37% PA) + distilled water, GPG: placebo gel that simulates 37% PA + 5% Gluma, and GAG: 37% PA + 5% Gluma. Two visual analog scales (VASs) were used to measure DH after tactile and evaporative stimulation four times. The HRQoL was recorded using a DH experience questionnaire (DHEQ). Statistical analysis of DH data was performed using Friedman vs. Kruskal-Wallis tests. DHEQ data were analyzed using Wilcoxon vs. Mann-Whitney tests and a simple logistic regression (alpha= 0.05). Result(s): The GPG and GAG groups showed significantly lower DH than GP (p