Development of green spectrophotometric method for determination of metoclopramide hydrochloride

Abstract

A simple, sensitive and green spectrophotometric method for the determination of metoclopramide hydrochloride (MTC) was developed. The method was based on the reaction of MTC with p-dimethylaminobenzaldehyde (DAB) in acidic aqueous medium (pH 2) in the presence of anionic surfactant sodium dodecyl sulfate (SDS) to give a yellow colored Schiff's base with a maximum absorbance at 452 nm. Obedience to Beer's law is achieved in the concentration range 0.2-18.0 μg mL-1 (5.6×10-7 - 5.1×10-5 mol L-1), with relative error about 1%, relative standard deviation of less than 0.8% and molar absorptivity 3.02×104 L mol-1cm-1. The effect of the presence of some common pharmaceutical additives was investigated. The developed procedure was successfully applied to the determination of the drug in pharmaceutical formulations.