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A 'Clicked'tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level

Scientific Reports (2014) 4
DOI: 10.1038/srep05513
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Abstract

A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.

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Zhang, H. L., Zang, Y., Xie, J., Li, J., Chen, G. R., He, X. P., & Tian, H. (2014). A ’Clicked’tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level. Scientific Reports, 4. https://doi.org/10.1038/srep05513

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