BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. CONCLUSION: An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.
CITATION STYLE
Lenze, U., Pohlig, F., Mühlhofer, H., Lenze, F., Toepfer, A., Rechl, H., … Straub, M. (2015). Do human tumor-associated viruses play a role in the development of synovial sarcoma? Clinical Sarcoma Research, 5(1). https://doi.org/10.1186/s13569-015-0027-x
Mendeley helps you to discover research relevant for your work.