EORTC-QLQ-C30 and SKINDEX-29 measurement of health-related quality of life in patients with mycosis fungoides and Sézary syndrome: Real-world data in Spanish patients (MICADOS Study)

Abstract

Background: Few studies have explored the impact of cutaneous T-cell lymphoma (CTCL) on health-related quality of life (HRQoL) and compared it to other patients with cancer. Objectives: The primary objective of the study was to assess the QoL of patients diagnosed with the mycosis fungoides (MF) and Sézary syndrome (SS) types of CTCL in Spain. Methods: A cross-sectional observational study was completed recruiting adult patients with MF and SS, exploring the European Organisation for Research and Treatment of Cancer-Core Quality of Life Questionnaire, version 3 (EORTC-QLQ-C30v3) and Skindex-29 HRQoL and itching intensity. Results: A total of 141 patients [81 males (57.4%) and mean age of 63.6 years (95% CI: 61.4–65.7)], were included. EORTC-QLQ-C30 global health status showed worse scores in CTCL patients compared to healthy population (p < 0.05) and did not differ from other patients with cancer. The physical and role functioning of CTCL patients were better than other patients with cancer (p < 0.05) but worse than healthy population (p < 0.05). The social functioning was similar to other patients with cancer but worse than healthy (p < 0.05). In the global health status, better scores were observed with aging (p = 0.023) and worse scores in patients with Eastern Cooperative Oncology Group (ECOG)-1 versus ECOG-0 (p = 0.01). The Skindex-29 global score was 28.5 (95% CI: 24.8–32.3), being worst at higher clinical stage (p < 0.05) and at higher pruritus intensity (p < 0.001) and better for older patients (p < 0.001). More itching was related to female sex (p = 0.016), younger patients (p = 0.035), higher ECOG (p < 0.05) and higher m-SWAT scores (p = 0.006). Conclusions: These results allow mapping HRQoL affectation in CTCL patients. Global health status in MF/SS was like other patients with cancer and worse than the age-matched healthy population. The highest impact in Skindex-29 and EORTC-QLQ-C30 was associated with young age, ECOG, pruritus and disease stage.