Effects of respiratory motion on volumetric and positional difference of GTV in lung cancer based on 3DCT and 4DCT scanning

Abstract

Differences in gross target volume (GTV) and central point positions among moving lung cancer models constructed by CT scanning at different frequencies were compared, in order to explore the effect of different respiratory frequencies on the GTV constructions in moving lung tumors. Eight models in different shapes and sizes were established to stimulate lung tumors. The three-dimensional computed tomography (3DCT) and four-dimensional computed tomography (4DCT) scanning were performed at 10, 15 and 20 times/min in different models. Differences in GTV volumes and central point positions at different motion frequencies were compared by means of GTV3Ds (GTV 3D-10 , GTV 3D-15 , GTV 3D-20 ) and IGTV4Ds (IGTV 4D-10 , IGTV 4D-15 , IGTV 4D-20 ). Volumes of GTV 3D-10 , GTV 3D - 15 , GTV 3D-20 were 12.41±14.26, 10.38±11.18 and 12.50±15.23 cm 3 respectively (P=0.687). Central point coordinates in the x-axis direction were-8.16±96.21,-8.57±96.08 and-8.56±95.73 respectively (P=0.968). Central point coordinates in the y-axis direction were 108.22±25.03, 110.41±22.47 and 109.04±24.24 (P=0.028). Central point coordinates in the z-axis direction were 65.19±13.68, 65.43±13.40 and 65.38±13.17 (P=0.902). The difference was significant in the y-axis direction (P=0.028). Volumes of IGTV 4D-10 , IGTV 4D-15 , IGTV 4D-20 were 17.78±19.42, 17.43±19.56 and 17.44±18.80 cm 3 (P=0.417). Central point coordinates in the x-axis direction were-7.73±95.93,-7.86±95.56 and-7.92±95.14 (P=0.325). Central point coordinates in the y-axis direction were 109.41±24.54, 109.60±24.13 and 109.16±24.28 (P=0.525). Central point coordinates in the z-axis direction were 65.52±13.31, 65.59±13.39 and 65.51±13.34 (P=0.093). However, the central point position of GTV in the head and foot direction by 3DCT scanning was severely affected by the respiratory frequency.