RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

Abstract

Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.