The trends of the antioxidant drug "U-74389G" on potassium levels during hypoxia reoxygenation injury in rats

Abstract

Background: This experimental study examined the trends of the antioxidant drug "U-74389G", on a rat model and particularly in a hypoxia - reoxygenation (HR) protocol. The trends of that molecule were studied biochemically using blood mean potassium levels. Methods: 40 rats of mean weight 231.875 g were used in the study. Potassium (K+) levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D. Results: U-74389G administration non significantly decreased the K+ levels by 2.14%±5.06% (p= 0.6730). Reoxygenation time non-significantly increased the K+ levels by 8.66%±4.85% (p= 0.0934). However, U-74389G administration and reoxygenation time together non-significantly increased the K+ levels by 2.07%±3.03% (P= 0.4853). Conclusions: U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short-term trends on potassium levels. Perhaps, a longer study time or a higher drug dose may reveal clearer and significant effects.