Terpenoids and steroids from Trichilia species

Abstract

The methanol extract of stems of Trichilia claussenii yielded three new sesquiterpenoids: 14-hydroxyelemol, germacra- 10(14)-en-9,11,15-triol and germacra-3,10(14)-dien-9,11-diol-4-carbaldehyde. Two known sesquiterpenoids β-eudesmol, cryptomeridiol and the triterpenoid 22,25-dihydroxy-9β, 19-cyclolanost-23-en-3-one were also isolated. The dichloromethane extract from the leaves of T. lepidota afforded a mixture of hydrocarbons (C29H60, C31H64 and C33H68), a mixture of the sesquiterpenes caryophyllene and humulene epoxides, spathulenol, and a series of sterols: 24-methylene- 12β-hydroxycholesterol, 24-methyl- 12β-hydroxycholest-4-en-3-one, 24-methylene- 12β-hydroxycholest-5-ene-3-palmitate; a mixture of 24-methylenecholesterol, campesterol, stigmasterol and β-sitosterol; besides α-tocoferol and phytol. From the methanol extract it was isolated N-methyl-4-hydroxyproline. The structures of the isolated compounds were determined on the basis of spectroscopic analysis.