Recent Advances in the Synthesis of Aminoglycoside Antibiotics

Abstract

Aminoglycoside antibiotics have established an important position in medicine and synthetic chemistry in this field has recently been developed. A review is provided of general synthetic schemes which we have developed for the total synthesis of streptomycin, dihydrostreptomycin, kanamycins, butirosin B, neomycin C, and others. Resistant bacteria are a serious subject in present chemotherapy and, the mechanisms of resistance have recently been revealed by medical microbiologists. In the light of these mechanisms, an effort has been made to synthesise compounds, active against resistant bacteria, by extension of the above mentioned synthetic schemes and by derivation from natural antibiotics. © IUPAC