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c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming

  • Zhang Q
  • Cui K
  • Yang X
  • et al.
Clinical and Translational Medicine (2023) 13(1)
DOI: 10.1002/ctm2.1164
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Abstract

Graphical Abstract • Global expression patterns, dysregulation profiles, genomic alterations and clinical relevance of 168 metabolic rate-limiting enzymes and their relationship with Myc were determined in human cancers. • Metabolic rate-limiting enzyme IMPDH2 interacts with IMPDH1 to stabilize IMPDH1. • Myc promotes de novo GTP biosynthesis in human cancers by transcriptional activation of IMPDH1 and IMPDH2. Clin. Transl. Med. 2023;13:e1164. wileyonlinelibrary.com/journal/ctm2 https://doi.

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APA

Zhang, Q., Cui, K., Yang, X., He, Q., Yu, J., Yang, L., … Lan, P. (2023). c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. Clinical and Translational Medicine, 13(1). https://doi.org/10.1002/ctm2.1164

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