Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer

Nabil A. Siddiqui; Li Zhang; Gabriel DeLeon; Nada Naguib; Tuo Zhang; Thomas P. Quinn; Feng Chen; Virginia Aragon Sanabria; Anusha Aditya; Daniel Penarete; Sebastien Monette; Fabio Socciarelli; Miles Pourbaghi; Rachel Lee; Chan Lee; Pat B. Zanzonico; Howard I. Scher; Michael Overholtzer; Ulrich Wiesner; Jedd D. Wolchok; Michelle S. Bradbury

Journal Article

Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer

Siddiqui N
Zhang L
DeLeon G
et al.

Cancer Research (2026) OF1-OF19

DOI: 10.1158/0008-5472.can-25-4954

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Siddiqui, N. A., Zhang, L., DeLeon, G., Naguib, N., Zhang, T., Quinn, T. P., … Bradbury, M. S. (2026). Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer. Cancer Research, OF1–OF19. https://doi.org/10.1158/0008-5472.can-25-4954

Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer

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