Three component reaction of indane-1,2,3-trione, tosylmethyl isocyanide and benzoic acid derivatives

Abstract

The Passerini reactions of indane-1,2,3-trione, tosylmethyl isocyanide, and benzoic acid derivatives proceed at room temperature giving sterically congested 2,2-disubstituted indane-1,3-dione derivatives in quantitative yield. The reactions are one-pot, and the products obtained did not require any purification. ©ARKAT-USA, Inc.