Abstract
A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given every 2 hours. The results support the value of pharmaceutical appooaches to the stabilisation of circulating levodopa levels in the treatment of Parkinson's disease.
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CITATION STYLE
Juncos, J. L., Fabbrini, G., Mouradian, M. M., Serrati, C., Kask, A. M., & Chase, T. N. (1987). Controlled release levodopa treatment of motor fluctuations in Parkinson’s disease. Journal of Neurology Neurosurgery and Psychiatry, 50(2), 194–198. https://doi.org/10.1136/jnnp.50.2.194
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