Effects of Coenzyme Q10Supplementation on Lipid Profiles in Adults: A Meta-Analysis of Randomized Controlled Trials

Abstract

Context: Previous meta-Analyses have suggested that the effects of coenzyme Q10 (CoQ10) on lipid profiles remain debatable. Additionally, no meta-Analysis has explored the optimal intake of CoQ10 for attenuating lipid profiles in adults. Objective: This study conducted a meta-Analysis to determine the effects of CoQ10 on lipid profiles and assess their dose-response relationships in adults. Methods: Databases (Web of Science, PubMed/Medline, Embase, and the Cochrane Library) were systematically searched until August 10, 2022. The random effects model was used to calculate the mean differences (MDs) and 95% CI for changes in circulating lipid profiles. The novel single-stage restricted cubic spline regression model was applied to explore nonlinear dose-response relationships. Results: Fifty randomized controlled trials with a total of 2794 participants were included in the qualitative synthesis. The pooled analysis revealed that CoQ10 supplementation significantly reduced total cholesterol (TC) (MD-5.53mg/dL; 95% CI-8.40,-2.66; I2 = 70%), low-density lipoprotein cholesterol (LDL-C) (MD-3.03mg/dL; 95% CI-5.25,-0.81; I2 = 54%), and triglycerides (TGs) (MD-9.06mg/dL; 95% CI-14.04,-4.08; I2 = 65%) and increased high-density lipoprotein cholesterol (HDL-C) (MD 0.83mg/dL; 95% CI 0.01, 1.65; I2 = 82%). The dose-response analysis showed an inverse J-shaped nonlinear pattern between CoQ10 supplementation and TC in which 400-500mg/day CoQ10 largely reduced TC (χ2 = 48.54, P