In vitro Differentiation of Mouse Th0, Th1 and Th2 from Naïve CD4 T Cells

Abstract

In vitro differentiation of helper T cells of various lineages is frequently used in T helper cell study. Naïve CD4 T cells can differentiate into certain lineage of T help cells in vitro in the presence of specific stimulatory cytokines and inhibition of cytokines that are essential for the differentiation of other lineages.