Abstract
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Smitka, T. A., Deeter, J. B., Hunt, A. H., Mertz, F. P., Ellis, R. M., Boeck, L. D., & Yao, R. C. (1988). A83586C, a new depsipeptide antibiotic. The Journal of Antibiotics, 41(6), 726–733. https://doi.org/10.7164/antibiotics.41.726
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