Burden of rodent-borne viruses in rodents and zoonotic risk in humans in Cambodia

Abstract

Rodents can carry viruses that may spread to humans, sometimes causing serious diseases. However, little was known about the presence of these viruses in Cambodia or their potential impact on human health. This study investigated rodent populations across urban, semi-urban, and rural areas and tested both rodents and humans for three key viruses: arenavirus, hantavirus, and hepatitis E virus. The findings confirm the presence of these viruses in rodents and indicate human exposure, particularly in urban areas. Factors such as urban residency and living in flood-prone areas were associated with an increased risk of exposure. These results emphasize the need for improved rodent control, waste management, and public awareness of zoonotic disease risks. A better understanding of virus transmission dynamics will help guide health officials in developing effective strategies to prevent infections and protect communities.