The preparation of protected arabinonucleosides

Abstract

A general procedure is described for the preparation of protected arabinonucleosides. Protection at the 5′-position involves triphenylmethyl groups (DMT and MMT) while the tert-butyldimethylsilyl (TBDMS) group is used to protect the 2′- or 3′-positions. The effects of novel catalysts on the position of silylation have been determined, leading to highly selective reactions at 2′- or 3′-positions.