Abstract
Dinucleotide cap analogs containing tetraphosphate bridge modified by replacing one of the bridging oxygen atoms with methylene group were synthesized. The analogs have been examined for their stability towards enzymatic hydrolysis by human DcpS and binding affinity for eIF4E. Their inhibitory properties in rabbit reticulocyte lysate (RRL) translational system were studied.
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CITATION STYLE
Rydzik, A., Zuberek, J., Kowalska, J., Lukaszewicz, M., Darzynkiewicz, E., & Jemielity, J. (2008). Synthesis and biochemical studies of tetraphosphate 5’ mRNA cap analogs bearing bisphosphonate modification. Nucleic Acids Symposium Series (2004), (52), 287–288. https://doi.org/10.1093/nass/nrn145
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