Dynamic combinatorial chemistry: The unexpected choice of receptors by guest molecules

Abstract

(Figure Presented) Survival of the fittest? Amplification of the best receptor from a dynamic combinatorial library does not always proceed according to survival of the "fittest". However, it has recently resulted in the discovery of some unexpected receptors for various substrates, as illustrated by the example of a catenane receptor (see picture; green) for the neurotransmitter acetylcholine (red). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.