Antibacterial evaluation of cnicin and some natural and semisynthetic analogues

Abstract

Some ester derivatives of salonitenolide have been prepared from cnicin, a germacranolide sesquiterpenoid. The compounds were tested for their antibacterial activity. The 8,15-diesters showed a good activity, comparable with that of cnicin. The 15-monoester compounds were not very active showing that esterification at the C-8 position is an important structural feature for antibacterial properties.