Abstract
Moxifloxacin-resistant Mycobacterium tuberculosis mutants were selected in vitro using different concentrations of moxifloxacin. gyrA mutations at codons 88 and 94 were associated with resistance (defined as an MIC of>2 μg/ml) (P<0.0001 and P 0.0053, respectively). Despite the presence of gyrA mutations, moxifloxacin significantly impedes bacterial growth, supporting its use for the treatment of ofloxacin-resistant M. tuberculosis. Copyright © 2014, American Society for Microbiology.
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CITATION STYLE
McGrath, M., Van Pittius, N. C. G., Sirgel, F. D. A., Van Helden, P. D., & Warren, R. M. (2014). Moxifloxacin retains antimycobacterial activity in the presence of gyra mutations. Antimicrobial Agents and Chemotherapy, 58(5), 2912–2915. https://doi.org/10.1128/AAC.02583-13
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