Algorithm for early diagnosis of contrast-induced nephropathy using biomarkers of renal damage

Abstract

The aim of the study was to develop an algorithm for early diagnosis of contrast-induced nephropathy using renal damage biomarkers cystatin C, nephrin, and lipocalin 2. Materials and Methods. Eighty-four patients, who for the first time underwent transcutaneous coronary intervention with radiocontrast agents, were included in the study. Group 1 was composed of patients with diabetes mellitus type 2 (n=44), group 2 consisted of patients without carbohydrate metabolism impairment (n=40). All patients were determined the concentration of renal damage biomarkers before and after the procedure. Results. Cystatin C, nephrin, and lipocalin 2 have been established to have high sensitivity and specificity. Determining them for 3 days enables objective assessment of the contrast-induced nephropathy dynamics. The proposed algorithm with biomarker application makes it possible to predict the development of acute renal insufficiency during operative interventions on the coronary arteries with introduction of contrast agents, and to carry out preventive therapy and intensive rehydration.