An in vitro study on the toxoplasmacidal activity of lonomycin A in host cells

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Abstract

Lonomycin A at various concentrations was tested for its inhibitory effect on Toxoplasma multiplication in host cells cultured in vitro. Results indicated that lonomycin A at a concentration of 0.01 μg per ml in TC-199 medium demonstrated a high degree of antitoxoplasma activity with complete inhibition of Toxoplasma multiplication in the host cells. Lymphokines, a supernatant produced from spleen cells of mice infected chronically with Toxoplasma gondii, inhibited Toxoplasma multiplication in mice macrophage and kidney cell monolayers. However, lonomycin A inhibited completely Toxoplasma multiplication in non-specific cells, i.e. not only in mice macrophages and kidney cells but also in cells of human and other animal species. © 1981, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Miyagami, T., Takei, Y., Matsumoto, Y., Suzuki, N., Otake, N., Mizoue, K., … Ozeki, M. (1981). An in vitro study on the toxoplasmacidal activity of lonomycin A in host cells. Journal of Antibiotics, 34(2), 218–223. https://doi.org/10.7164/antibiotics.34.218

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