The power-proportion method for intracranial volume correction in volumetric imaging analysis

Abstract

In volumetric brain imaging analysis, volumes of brain structures are typically assumed to beproportional or linearly related to intracranial volume (ICV). However, evidence abounds thatmany brain structures have power law relationships with ICV. To take this relationship intoaccount in volumetric imaging analysis, we propose a power law based method- the powerproportionmethod-for ICV correction. The performance of the new method is demonstratedusing data from the PREDICT-HD study.