Effect of administration of fungal mykotoxin (gliotoxin) on clinical and serobiochemical parameters in camels

Abstract

The main objective of this study was to determine the effect of administration of fungal mycotoxin (Gliotoxin) on clinical and serobiochetnical parameters in camels. A bolus of 0.1 μg kg-1 b.wt. of gliotoxin was administered intravenously to camels. The treated camels were lethargic and decreased their appetite from day 3 onwards. The toxin administration decreased the protein and glucose concentration of serum. The increased activity of aspartate amino transferase, gamma glutamyl-transferase, sorbitol dehydrogenase and alkaline phosphatase due to mycotoxin administration was indicative of liver damage. High concentration of urea nitrogen and creatinine in treated animals was a characteristic of renal injury. In conclusion, the gliotoxin is acutely toxic to camels effecting liver and kidney function. © 2009 Asian Network for Scientific Information.