Influence of Green Solvent Extraction on Phytochemicals, Potential Antidiabetic and In Vitro Anti-Inflammatory Activities of Pseuderanthemum palatiferum (Nees.) Radlk. Leaves

Abstract

Pseuderanthemum palatiferum (Nees.) Radlk., belonging to the Acanthaceae family, is commonly cultivated in Vietnam and Thailand for food and medicinal uses. The aim of the study was to compare phenolic composition, antioxidant, potential anti-inflammatory and antidiabetic activities of different extracts obtained from ethanol, 80% ethanol and water. The use of these solvents significantly affected the extractability of phytochemical classes, phenolic contents and bioactivities in the extracts. The extract obtained from 80% ethanol contained the highest amount of phenolics (113.74 ± 26.17 mg GAE/g). It also appeared to be more suitable for recovering phenolic constituents in P. palatiferum leaves. The extracts obtained from ethanol and 80% ethanol showed significantly higher antioxidant potential and inhibition of α-glucosidase compared to water. Regarding inhibition of bovine albumin denaturation, no differences were observed for the extracts at the examined concentration. The research helps better understand phytochemical contents and potential health benefits of P. palatiferum, which could be used for development of new plant-derived agents for disease prevention and treatment.