A novel and direct synthesis of 2-alkyl-5-aryl disubstituted oxazoles

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Abstract

A direct and efficient method for the preparation of 2-alkyl-5-aryl disubstituted oxazoles was realized by reaction of aromatic α-methyl ketones with various aliphatic nitriles in the presence of T1(OTf)3.

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Lee, J. C., & Hong, T. (1997). A novel and direct synthesis of 2-alkyl-5-aryl disubstituted oxazoles. Tetrahedron Letters, 38(52), 8959–8960. https://doi.org/10.1016/S0040-4039(97)10362-8

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