Effectiveness of turmeric (Curcuma longa linn) extract gel (eg) on wound healing in female rats (rattus novergicus)

Abstract

Objective: The purpose of this study was to identify differences in wound healing and wound healing time at each concentration of turmeric extract gel (Curcuma longa Linn) and base gel on days 3, 7 and 14, and identify the most effective turmeric extract gel for wound healing in cuts female rats (Rattus Novergicus). Method: This study was an experimental laboratory using a post-test only with a control group. This study used 16 female rats, 3 treatment groups, and 1 control group (each group consisted of 4 mice). Female rats were injured in the back section by slash-ing along 1.5 cm with a depth of 0.2 cm. The treatment group was given turmeric extract gel with a concentration of 5%, 10%, 15%, and the control group was only given a gel base. This research was conducted for 14 days of topical turmeric extract gel by giving 2 times a day. The normality test uses the Shapiro Wilk test, then the Kruskal Wallis test, and continued with the Post-Hoc Mann-Whitney. Results: The mean on the 3rd day of the EG group was 5% (0.95cm), the EG group was 10% (0.98 cm), the group was 15% (1.23 cm), and the control group (1.25 cm). On the 7th day EG 5% (0.58 cm), EG 10% (0.65 cm), EG 15% (0.73 cm) and the control group (1 cm). On day 14 showed wound healing in the treatment group, but the control group showed mean wound length on day 14 (0.15 cm). Test results on day 3 obtained p = 0.007, on day 7 obtained p= 0.010 and on day 14 obtained p-value = 0.017. P values on days 3, 7, and 14 showed significant differences with p<0.05. Conclusion: There are differences in wound healing and wound healing time at each concentration of turmeric extract gel. Turmeric extract gel concentration is the most effective healing wound cuts in female rats, namely the treatment group given EG 5%.