Antidiabetic and Antioxidant Activities of Crinum jagus Extracts on Induced Diabetes Rats MACAPOS 1

Abstract

The antioxidant and antidiabetic activities of aqueous and the hydroethanolic extracts of C. jagus were investigated on diabetic rats MACAPOS 1. Diabetes was induced on 6-8 weeks old wistar rats with high sugar diet (HSD) associated, one month after the beginning of the HSD, with dexamethasone (DXM) injection (25 µg/kg once every 2 days during 3 weeks). During 50 days, diabetic rats orally received Metformine (38 mg/kg bw), C. jagus hydroethanolic (75, 150 mg/kg bw) or aqueous (150 mg/kg bw) extracts. Treatment with extracts caused significant (P< 0.01) decrease in fasting glycemia, creatinemia, proteinuria, urine volume with concomitant increase in creatinuria, proteinemia, superoxide dismutase, catalase and thiol proteins. C. jagus extracts restored the imbalance of seric and urinary electrolytes, and significantly (P<0.01) increased peripheral sensibility to pain; the hydroethanolic extract was, in a dose dependant manner, more effective than aqueous extract and metformine. These results indicated that C. jagus extracts could possess antioxidant and antidiabetic activities on MACAPOS 1 diabetic rats, and could also improve renal and neurological diabetes damage. The results thus support the use of C. jagus in African folk medicine, mostly in diabetes mellitus treatment and likely its complications.