Development of poly (acrylamide-co-diallyldimethylammoniumchloride) nanogels and study of their ability as drug delivery devices

Abstract

Bio-degradable polymers have attracted much attention and been familiar to be the most promising drug carrier materials for the last several years due to their wonderful virtues such as easily existing, non-toxic, bio-compatible, and can be modified easily. Herein, we report the synthesis of new drug carrier poly (acrylamide-co-diallyldimethylammoniumchloride) nanogels (PAD-NG) by dispersion polymerization technique using free radical initiator potassium persulphate (KPS), potassium hydrogen sulphate (KHSO4) as a co-initiator and chemical cross-linker N, N-methylene bisacrylamide (NN-MBA). The developed nanogels are characterized for their structure, size and morphology. The average size of the nanogels was about 100 nm. These nanogels were used as intracellular drug delivery vehicle by encapsulating 5-fluorouracil (5-FU) with efficiency of 76.34%. Further, placebo nanogels showed negligible hemolytic activity and cytotoxicity against neuroblastoma cells.