Association of nucleotide-binding oligomerization domain-like receptor family pyrin domaincontaining protein 3 polymorphisms with systemic lupus erythematosus disease activity and biomarker levels a case-control study in Chinese population

Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with considerable genetic predisposition. Nucleotidebinding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) is crucial for the innate immunity and implicated in SLE pathogenesis. Accordingly, we conducted a case-control study to find the association of NLRP3 variations with SLE susceptibility and disease activity. Three single nucleotide polymorphisms of NLRP3 (rs3806268, rs4612666, and rs10754558) were genotyped in 400 SLE patients and 400 healthy controls; the patients were further divided into mild-to-moderate or high disease activity subgroup. Serum cytokines, complements, and autoantibodies were also detected. We found that rs4612666 TT genotype conferred a higher risk of severe disease activity with adjusted odds ratio=2.08, P=.02 and adjusted odds ratio =2.34, P=.01 in the codominant and recessive model, respectively. Nevertheless, there was no association between the 3 single nucleotide polymorphisms of NLRP3 gene and SLE susceptibility. In addition, C4 decreased significantly in rs3806268 GG (P