A new role for E2F-1 in checkpoint control.

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Abstract

In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

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Stevens, C., & La Thangue, N. B. (2003). A new role for E2F-1 in checkpoint control. Cell Cycle (Georgetown, Tex.). https://doi.org/10.4161/cc.2.5.462

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