The effect of phlorotannin Sargassum sp. extract on colon profile of diabetic rats

Abstract

Diabetes mellitus is a metabolic disorder marked by hyperglycemia. Polyphenol is capable of being scavenger of free radicals by transferring its hydroxyl atom. Polyphenol, which contained in brown algae, is phlorotannin. This study aimed to investigate the effects of phlorotannin from Sargassum sp. on blood glucose and histopathology of the colon of diabetic rats. Research steps were extraction of a phlorotannin, the establishment of the diabetic model, general histological staining, histopathology analysis, and determination of phlorotannin contain. This research was comprised of seven groups and five replications of treatment. Diabetic rats were prepared by injection of 40 mg/kg BW streptozotocin in intraperitoneal. The results showed that Sargassum sp. extracts were capable of diminishing blood glucose level, likewise repairing the histopathology of the colon. A dose of 600 mg/kg BW is the best dose of extract Sargassum sp. on improving the colon profile of diabetic rats.