Clinical characteristics and time of initiation of thrombolytic treatment in patients with Ischemic Cerebrovascular Accident in the Stroke Unit of the Emergency Service of the Hospital de Clínicas

Abstract

Introduction: intravenous thrombolysis revolutionized the therapy of patients with ischemic strokes. Objective: determine the clinical characteristics and time of initiation of thrombolytic treatment in patients with ischemic stroke in the Stroke Unit of the Hospital de Clínicas. Methodology: retrospective, observational, descriptive, cross-sectional study, non-probabilistic sampling, of patients with a diagnosis of ischemic stroke admitted to the Stroke Unit of the Hospital de Clínicas, from January 2015 to June 2022. Sociodemographic variables, start time of thrombolytic treatment, NIHSS at admission, 24 hours and 5 days, ASPCT scale, glycemia, systolic and diastolic blood pressure, risk factors for heart disease, hemorrhagic transformation. Results: 10 % of patients met thrombolysis criteria, mean age 62 ± 1, male 59 %. Average time from hospital admission to the thrombolytic drip was 44 ± 2 minutes and from the onset of symptoms to the thrombolytic drip was 195 ± 5 minutes. The most frequent cardiovascular risk factors were High Blood Pressure and Diabetes Mellitus; symptomatic hemorrhagic transformations occurred in 5 % of the thrombolyzed patients. Conclusion: 10 % of patients met criteria for thrombolysis. The mean time from hospital admission to the fibrinolytic drip was 44 minutes and from the onset of symptoms to the thrombolytic drip was 195 ± 5 minutes. The most frequent risk factors for heart disease were High Blood Pressure and Diabetes Mellitus, 5% of symptomatic hemorrhagic transformation occurred.