A tyrosinase inhibitor, daedalin A, from mycelial culture of Daedalea dickinsii

Abstract

A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC50: 194 μM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC50: 16.9 μM) and superoxide anion scavenging activity (IC50: 28.5 μM).