Abstract
Recently, we showed that Mp1p is an important virulence factor of Talaromyces marneffei, a dimorphic fungus phylogenetically closely related to Aspergillus fumigatus. In this study, we investigated the virulence properties of the four Mp1p homologues (Afmp1p, Afmp2p, Afmp3p, and Afmp4p) in A. fumigatus using a mouse model. All mice died 7 days after challenge with wild-type A. fumigatus QC5096, AFMP1 knockdown mutant, AFMP2 knockdown mutant and AFMP3 knockdown mutant and 28 days after challenge with AFMP4 knockdown mutant (P
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Woo, P. C. Y., Lau, S. K. P., Lau, C. C. Y., Tung, E. T. K., Au-Yeung, R. K. H., Cai, J. P., … Yuen, K. Y. (2018). Mp1p homologues as virulence factors in Aspergillus fumigatus. Medical Mycology, 56(3), 350–360. https://doi.org/10.1093/mmy/myx052
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