Block matching: A general framework to improve robustness of rigid registration of medical images

Abstract

In order to improve the robustness of rigid registration algorithms in various medical imaging problems, we propose in this article a general framework built on block matching strategies. This framework combines two stages in a multi-scale hierarchy. The first stage consists in finding for each block (or subregion) of the first image, the most similar subregion in the other image, using a similarity criterion which depends on the nature of the images. The second stage consists in finding the global rigid transformation which best explains most of these local correspondances. This is done with a robust procedure which allows up to 50% of false matches. We show that this approach, besides its simplicity, provides a robust and efficient way to rigidly register images in various situations. This includes for instance the alignment of 2D histological sections for the 3D reconstructions of trimmed organs and tissues, the automatic computation of the mid-sagittal plane in multimodal 3D images of the brain, and the multimodal registration of 3D CT and MR images of the brain. A quantitative evaluation of the results is provided for this last example, as well as a comparison with the classical approaches involving the minimization of a global measure of similarity based on Mutual Information or the Correlation Ratio. This shows a significant improvement of the robustness, for a comparable final accuracy. Although slightly more expensive in terms of computational requirements, the proposed approach can easily be implemented on a parallel architecture, which opens potentialities for real time applications using a large number of processors.