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Carbonic Anhydrase Activators. VII.1) Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles

Biological and Pharmaceutical Bulletin (1993) 16(12) 1236-1239
DOI: 10.1248/bpb.16.1236
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Abstract

Acorrelation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed. © 1993, The Pharmaceutical Society of Japan. All rights reserved.

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Supuran, C. T., Balaban, A. T., Cabildo, P., Claramunt, R. M., Lavandera, J. L., & Elguero, J. (1993). Carbonic Anhydrase Activators. VII.1) Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles. Biological and Pharmaceutical Bulletin, 16(12), 1236–1239. https://doi.org/10.1248/bpb.16.1236

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