Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer

Abstract

Overexpression of the EGFR ligands amphiregulin (AREG)/ epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic colorectal cancer. High AREG/EREG may be coupled with negative hyper-selection (i.e., lack of genomic drivers of primary resistance beyond RAS and BRAF) to identify patients with right-sided tumors and potential sensitivity to EGFR blockade.