Acquired Resistance to KRAS G12C Inhibition in Cancer

  • Awad M
  • Liu S
  • Rybkin I
  • et al.
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Abstract

Abstract Background Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (...

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Awad, M. M., Liu, S., Rybkin, I. I., Arbour, K. C., Dilly, J., Zhu, V. W., … Aguirre, A. J. (2021). Acquired Resistance to KRAS G12C Inhibition in Cancer. New England Journal of Medicine, 384(25), 2382–2393. https://doi.org/10.1056/nejmoa2105281

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