Prognostic factors of pulmonary metastasectomy (PME) in hepatocellular carcinoma (HCC)

Abstract

Objective: To explore the prognostic factors of pulmonary metastasectomy (PME) for hepatocellular carcinoma (HCC) after curative liver resection. Methods: We retrospectively analyzed 42 HCC patients who had undergone PME after radical liver resection in Zhongshan Hospital,Fudan University.Univariate and multivariate analysis of survival were taken. Results:: The estimated 2- and 5-year overall survival (OS) rates after PME were 60.5% and 33.2%,respectively,and the disease-free survival (DFS) rates were 39.0% and 18.6%,respectively.The multivariate prognostic analysis revealed that disease-free interval (DFI)<12 months (P=0.009)and bilateral distribution (P=0.023) were risk factors for OS,while DFI<12 months (P=0.042) and positive HBsAg (P=0.012) were unfavorable factors for DFS. Conclusions: Survival benefit of HCC patients after PME was limited in those with shorter DFI and bilateral distribution.Intensive follow-up was required for those with short DFI and positive HBsAg.