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Noncoding RNAs in the regulation of DNA replication

Trends in Biochemical Sciences
DOI: 10.1016/j.tibs.2014.06.003
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Abstract

Noncoding RNAs (ncRNAs) have crucial roles in epigenetic, transcriptional, and post-transcriptional regulation. Recent studies have begun to reveal a role of ncRNAs in DNA replication. Here, we review the roles of ncRNAs in regulating different aspects of DNA replication in prokaryotic and eukaryotic systems. We speculate that ncRNAs might function to guide the origin recognition complex (ORC) to chromosomal DNA during replication initiation in higher eukaryotes. © 2014 Elsevier Ltd.

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Ge, X. Q., & Lin, H. (2014). Noncoding RNAs in the regulation of DNA replication. Trends in Biochemical Sciences. Elsevier Ltd. https://doi.org/10.1016/j.tibs.2014.06.003

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