Abstract
Lassa virus (LASV) is responsible for the deaths of thousands of peoplein West Africa annually. Genetic diversity among LASV strains isthe highest among the Arenaviridae and represents a great challengefor vaccine development. Guinea pigs vaccinated with a ML29 reassortantvaccine experienced sterilizing immunity and complete protectionwhen challenged on day 30 either with homologous virus or with thedistantly related Nigerian isolate. Simultaneous vaccination-challengeor challenge on day 2 after vaccination also protected 60-100% ofthe animals against both strains, but without sterilizing immunity.These results indicate that simultaneous replication of ML29 andLASV attenuates the virulence of LASV infection.
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CITATION STYLE
da Silva, J. A. T., Karimi, J., Mohsenzadeh, S., & Dobranszki, J. (2015). Allelopathic Potential of Select Gymnospermous Trees. Journal of Forest and Environmental Science, 31(2), 109–118. https://doi.org/10.7747/jfes.2015.31.2.109
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